Analysis of NOTCH1 mutations in monoclonal B-cell lymphocytosis.
نویسندگان
چکیده
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منابع مشابه
Monoclonal B-Cell Lymphocytosis
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 10(9)/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, cytopenias or autoimmune diseases. It is found in approximately 3-12% of normal persons depending on the accuracy of analytical techniques applied. According to the immunophenot...
متن کاملMonoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases.
BACKGROUND Monoclonal B-cell lymphocytosis is classified as 'high-count or clinical' monoclonal B-cell lymphocytosis and 'low-count or population' monoclonal B-cell lymphocytosis. Previously, 167 first-degree relatives pertaining to sporadic (non-familial) chronic lymphocytic leukemia families were studied and the presence of seven monoclonal B-cell lymphocytosis individuals was reported. OBJ...
متن کاملClinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.
PURPOSE To investigate the incidence and clinical relevance of classic and new prognostic markers, IGHV gene mutational status, and chromosomal abnormalities in clinical monoclonal B lymphocytosis (cMBL) compared with Rai stage 0 chronic lymphocytic leukemia (Rai0-CLL). EXPERIMENTAL DESIGN A group of 136 patients with cMBL and a group of 216 Rai0-CLL cases were investigated prospectively. R...
متن کاملHuman Cancer Biology Clinical Monoclonal B Lymphocytosis versus Rai 0 Chronic Lymphocytic Leukemia: A Comparison of Cellular, Cytogenetic, Molecular, and Clinical Features
Purpose: To investigate the incidence and clinical relevance of classic and newprognosticmarkers, IGHV gene mutational status, and chromosomal abnormalities in clinical monoclonal B lymphocytosis (cMBL) compared with Rai stage 0 chronic lymphocytic leukemia (Rai0-CLL). Experimental Design: A group of 136 patients with cMBL and a group of 216 Rai0-CLL cases were investigated prospectively. Resul...
متن کاملLow frequency mutations independently predict poor treatment-free survival in early stage chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
Recent studies employing next generation sequencing (NGS) technologies have identified novel recurring mutations in monoclonal B-cell lymphocytosis (cMBL) and chronic lymphocytic leukemia (CLL).NOTCH1 and SF3B1 mutations are the most prevalent and are associated with reduced survival independent of established clinical and biological variables. However, we have limited understanding of the impa...
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ورودعنوان ژورنال:
- Haematologica
دوره 97 1 شماره
صفحات -
تاریخ انتشار 2012